Prof. Dr. Manuel Liebeke

*Corresponding author is indicated with underlined

Preprints

• Saharuka, V., Vieira, L. M., Stuart, L., Ekelöf, M., Molenaar, M. R., Bailoni, A., Ovchinnikova, K., Soltwisch, J., Bausbacher, T., Jakob, D., King, M., Müller, M. A., Oetjen, J., Pace, C., Pinto, F. E., Strittmatter, N., Velickovic, D., Spengler, B., Muddiman, D. C., Liebeke, M., Janfelt, C., Goodwin, R., Eberlin, L. S., Anderton, C. R., Hopf, C., Dreisewerd, K., Alexandrov, T.,Biorxiv doi: https://doi.org/10.1101/2024.01.29.577354, “Large-Scale Evaluation of Spatial Metabolomics Protocols and Technologies“
• Kleiner, M., Polerecky, L., Lott, C., Bergin, C., Häusler, S., Liebeke, M., Wentrup, C., Musat, N., Kuypers, M. M. M., Dubilier, N., Biorxiv https://doi.org/10.1101/2023.11.25.568684, „Mechanism of high energy efficiency of carbon fixation by sulfur-oxidizing symbionts revealed by single-cell analyses and metabolic modeling“
• Alexandrov, T., Ovchinnikova, K., Palmer, A., Kovalev, V., Tarasov, A., Stuart, L., Nigmetzianov, R., Fay, D., Liebeke, M, …Key METASPACE Contributors,  biorxiv doi: https://doi.org/10.1101/539478, “METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease”  

peer-reviewed

2024

• Michellod, D., Liebeke, M., Nature Microbiology, in press; doi: 10.1038/s41564-023-01592-8, „Metabolic dialogue: host-compound shapes gut microbiota“
• Zuffa, S., …, Bourceau, P., Liebeke, M., …Dorrestein, P.
   Nature Microbiology , in press and bioRxiv 2023.07.20.549584; doi: https://doi.org/10.1101/2023.07.20.549584, „A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data“

2023

• Michellod, D., Bien, T., Birgel, D., Jensen, M., Kleiner, M., Fearn, S., Zeidler, C., Gruber-Vodicka, H. Dubilier, N., Liebeke, M., Science Vol 380, Issue 6644, 520-526 (2023), „De novo synthesis of phytosterols in animals”
• Borceau, P., Geier, B., Suerdieck, V., Bien, T., Soltwisch, J., Dreisewerd, K., Liebeke, M., Nature Protocols (https://doi.org/10.1038/s41596-023-00864-1) (2023), “Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in-situ fluorescence labeling”
• Buck-Wiese H.,, Andskog, MA., Nguyen, M, Bligh, M., Asmala, E., Vidal-Melgosa, S., Liebeke, M. Gustafsson, C., Hehemann, JH., PNAS 120 (1), e2210561119, „Fucoid brown algae inject fucoidan carbon into the ocean“
• Geier, B., Gil-Mansilla, E., Liutkeviciute, Z., Hellinger, R., Vanden Broeck, J., Oetjen, J., Liebeke, M., Gruber, C., PNAS Nexus doi.org/10.1093/pnasnexus/pgad144 (2023), “Multiplexed neuropeptide mapping in ant brains integrating microtomography and 3D mass spectrometry imaging“

2022

• Paredes, G., Viehboeck, T., Markert, S., Mausz, S., Sato, Y., Liebeke, M., König,L., Bulgheresi, S., Scientific Reports 12 (1), 9725 (2022), “Differential regulation of degradation and immune pathways underlies adaptation of the ectosymbiotic nematode Laxus oneistus to oxic-anoxic interfaces”
• Buck-Wiese, H., Andskog, M., Nguyen, NP, Bligh, M., Asmala, M., Liebeke, M., Hehemann, JH, PNAS 120 (1), e2210561119 (2022), “Fucoid brown algae inject fucoidan carbon into the ocean”
• Bourceau, P., Michellod, D, Geier, B., Liebeke, M., PeerJ Analytical Chemistry 4, e21 (2022), “Spatial metabolomics shows contrasting phosphonolipid distributions in tissues of marine bivalves”
• Sogin, M., Michellod, D., Borceau, P., Gruber-Vodicka, H., Seidel, M., Dubilier, N., Liebeke, M. , Nature Ecology and Evolution 6, 866–877 (2022) doi.org/10.1101/797522), “Sugars dominate the seagrass rhizosphere”
• Schorn, S. Ahmerkamp, S., Bullock, E., Weber, M., Lott, C., Liebeke, M., Lavik, G., Kuypers, MMM., Graf, J., Milucka, J., PNAS 2022 Vol. 119 No. 00 e2106628119 https://doi.org/10.1073/pnas.2106628119, “Diverse methylotrophic methanogenic archaea cause high methane emissions from seagrass meadows”

ältere Publikationen

• Janda, M., Seah, BK., Geier, B., Jakob, D., Beckmann, J., Liebeke, M. , Analytical Chemistry 93, 24, 8399–8407, “Determination of abundant metabolite-matrix adducts illuminate the dark metabolome of MALDI-massspectrometry imaging datasets”
• Geier, B., Oetjen, J., Ruthensteiner, B., Polikarpov, M.,  Gruber-Vodicka, H., Liebeke, M., PNAS 118 (27) e2023773118; https://doi.org/10.1073/pnas.2023773118, “Connecting structure and function from organisms to molecules in small animal symbioses through chemohisto-tomography”
• Breinlinger, S., Phillips, T. Haram, B., Mareš, J., Martínez Yerena, J.,Hrouzek, P., Sobotka, R., Henderson, M., Schmieder, P., Williams, S., Lauderdale, J., Wilde, DH., Gerrin, W., Kust, A., Geier, B., Liebeke, M., Enke, H., Niedermeyer, THJ, Wilde, S., Science 371 (6536), “A cyanobacterial neurotoxin causes Vacuolar Myelinopathy”
• Koch, E., Ruby, N., McFall Nigh, M., Liebeke, M., Journal of Experimental Biology, 223 (16). doi:10.1242/jeb.212860, „The impact of persistent colonization by Vibrio fischeri on the metabolome of the host squid Euprymna scolopes“
• Buck-Wiese, H., Fanuel, M., Liebeke, M., Hoang, KLM, Pardo-Vargas, A.,, Seeberger, PH., Hehemann, JH.,, Rogniaux, H., Jackson, GP., Ropartz, D, Journal of the American Society for Mass Spectrometry, 31 (6), 1249-1259 doi.org/10.1021/jasms.0c00087, “Discrimination of β-1,4 and β1,3 linkages in native oligosaccharides via charge transfer dissociation mass spectrometry.”
• Sichert, A., Corzett, CH., Schechter, MS., Unfried, F., Markert, S. Becher, D., Fernandez-Guerra, R., Liebeke, M., Schweder, T., Polz, M., Hehemann, JH., Nature Microbiology 5, 1026–1039(2020) (doi.org/10.1038/s41564-020-0720-2), “Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan”
• Hahn, C., Laso-Pérez, R., Vulcano, F., Vaziourakis, KM., Stokke, R., Steen, IH., Teske, A., Boetius, Liebeke, M., A., Amann, R., Knittel, K., Wegener, G., mBio 11 (2) doi.org/10.1128/mBio.00600-20, “Candidatus Ethanoperedens, a thermophilic genus of archaea mediating the anaerobic oxidation of ethane"
• Sogin, E., Puskas, E.. Dubilier, N., Liebeke, M. , Systems 4:e00638-19. doi.org/10.1128/mSystems.00638-19, „Marine metabolomics: a method for the nontargeted measurement of metabolites in seawater by gaschromatography mass spectrometry“
• Geier, B. Sogin, M., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N., Liebeke, M., Nature Microbiology 5 , 498–510, biorxiv doi: https://doi.org/10.1101/555045, „Spatial metabolomics of in situ, host-microbe interactions on the micrometre scale“
• Geier, B., Franke, M., Ruthensteiner, B., González Porras., M.A., Gruhl, A., Wörmer, L., Moosmann, J., Hammel, J.U., Dubilier, N., Leisch, N., Liebeke, M., Proceedings of SPIE, Developments in X-Ray Tomography (doi:10.1117/12.253065), “Correlative 3D anatomy and spatial chemistry in animal-microbe symbioses – Developing sample preparation for phase-contrast synchrotron radiation based micro-computed tomography and mass spectrometry imaging.“
• Seah B., Chakkia, A., Huettel, B., Zarzycki, J., Schada von Borzyskowski, L., Erb, T., Kouris, A. , Kleiner, M., Liebeke, M., Dubilier, N., Gruber-Vodicka, HR., mBio DOI: 10.1128/mBio.01112-19, „Sulfur-oxidizing symbionts without canonical genes for autotrophic CO₂ fixation”
• Gruber-Vodicka, H., Leisch, N., Kleiner, M., Liebeke, M., Hinzke, T., McFall Nigh, M., Hadfield, M., Dubilier, N., Nature Microbiology 2019, „Trichoplax microbiome the simplest animal lives in an intimate symbiosis with two intracellular bacteria “
• Liebeke, M., Puskas, E., Metabolites 9 (4), 68; 2019, “Drying enhances signal intensity for global GC-MS metabolomics”
• Jäckle, O., Seah,B., Tietjen, M., Leisch, N:, Liebeke, M., Kleiner, M., Berg, J., Gruber-Vodicka, HR., PNAS 116 (17) 8505-8514, 2019, „Chemosynthetic symbiont with a drastically reduced genome serves as primary energy storage in the marine flatworm Paracatenula”
• Berg, J., Pjevac, P. Sommer, T., Buckner, C., Philippi, M., Hach, P., Liebeke, M., Holtappels, M., Danza, F., Tonolla, M., Sengupta, A., Schubert, CJ., Milucka, J., Kuypers, MMM., Environmental Microbiology 21 (5), 1611-1626, “Dark aerobic sulfide oxidation by anoxygenic phototrophs in anoxic waters”
• Puentes, E., Liebeke, M., Markert, S., Harder, J., Metabolites 8 (1), 12, „Anaerobic Degradation of Bicyclic Monoterpenes in Castellaniella defragrans”
• Puentes, E., Liebeke, M., Markert, S., Harder, J., Journal of Biological Chemistry 293, 9520-9529., „Limonene dehydrogenase hydroxylates the allylic methyl group of cyclic monoterpenes in the anaerobic terpene degradation by Castellaniella defragrans”
• Urbaniak, T., Soto, M., Liebeke, M., Koschek, K., The Journal of Organic Chemistry 82 (8), 4050-4055, “Insight into the Mechanism of Reversible Ring-Opening of 1, 3-Benzoxazine with Thiols”
• Rochfort, S., Bailey-Wyatt, AM., Liebeke, M., Southam, AD., Viant, MR., Bundy, JG., European Journal of Soil Biology 78, 17-19 “Novel aromatic metabolites from the coelomic fluid of Eisenia earthworm species”
• Spurgeon, DJ., Liebeke, M., Kille, P., Anderson, C., Lawlor, A., Bundy, JG., Lahive, E., Applied Soil Ecology 108, 8-15 , “Ecological drivers influence the distributions of two cryptic lineages in an earthworm morphospecies”
• Hao, J., Liebeke, M., Sommer, U., Viant, M, Ebbels T., Bundy, JG., Analytical Chemistry 88 (5), 2583-2589, "Statistical Correlations between NMR Spectroscopy and Direct Infusion FT-ICR Mass Spectrometry Aid Annotation of Unknowns in Metabolomics"
• Schimak, M., Kleiner, M., Wetzel, S., Liebeke, M., Dubillier, N., Fuchs, B., Applied Environmental Microbiology (82 (1), 62-70), „MiL-FISH: Multilabeled Oligonucleotides for Fluorescence In Situ Hybridization Improve Visualization of Bacterial Cells"
• Liebeke, M., Strittmatter, N., Fearn, S., McPhail, D., Morgen, J., Kille, P., Fuchser, J., Takats, Z., Bundy, JG., Nature Communications 10.1038/ncomms8869, "Unique metabolites protect earthworms against plant polyphenols"
• Hao,J., Liebeke, M., Deneiro, M., Astle, W., Bundy, JG., Ebbels T., Nature Protocols 9,1416–1427, "Bayesian Deconvolution and Quantitation of Metabolites in Complex 1-D NMR Spectra Using BATMAN"
• Bundy, JG., Kille, P., Liebeke, M., Spurgeon, DJ., Environmental Science & Technology 2014, 48 (2), pp 885–886, "Metallothioneins may not be enough - the role of phytochelatins in invertebrate metal detoxification"
• Liebeke, M., Bruford, MW., Donelly, R., Ebbels, TMD., Kille, P., Lahive, E., Madison, R., Morgan, J., Pinto-Juma, G., Svendson, C., Spurgeon, DJ, Bundy, JG., Biology Letters 10 (9) 20140615, “Identifying biochemical phenotypic differences between cryptic species” 
• Krismer, B.; Liebeke, M.; Janek, D.; Rautenberg, M.; Hornig, G.; Weidenmaier, C.; Lalk, M.; Peschel, A., PloS Pathogens (10(1): e1003862), "Nutrient Limitation Governs Staphylococcus aureus Metabolism and Niche Adaptation in the Human Nose"
• Liebeke, M., Lalk, M. (review), Int. J. of Med. Microb. 304, pp 222–229, "Staphylococcus aureus metabolism under changing environmental conditions - a metabolomics perspective"
• Liebeke, M.*, Garcia-Perez, I.*, Anderson, CJ.*, Lawlor, AJ, Bennett, MH., Morris, CA., Kille, P., Spurgeon, DJ, Bundy, JG., PloS One  8(11): e81271, “Earthworms produce phytochelatins in response to arsenic.”
• Behrends,V., Bell, T., Liebeke, M., Cordes-Blauert, A., Ashraf, S., Nair, C., Zlosnik, J., Williams, H., Bundy, J. (2013), Journal of Biological Chemistry,288 (21):15098–15109, “Metabolite profiling to characterize disease-related bacteria: gluconate excretion by Pseudomonas aeruginosa mutants and clinical isolates from cystic fibrosis patients”
• Liebeke, M., Hao, J., Ebbels, T, Bundy, JG. (2013), Analytical Chemistry, “Combining simple spectral ordering approach with peak fitting for one-dimensional NMR quantitative metabolomics”
• Meier, T., Marcos, J., Wodke, AHJ., Liebeke, M., Gutiérrez-Gallego, R., Serrano, L. (2013), Molecular BioSystems 9, 1743-1755, “Comprehensive metabolome analysis and quantitative integration with proteomics data in Mycoplasma pneumoniae”
• Mader, D., Liebeke, M., Winstel, V., Leibig, M., Götz,^, F., Lalk M., Peschel,^, A. (2013), BMC Microbiology 2013, 13(1):7, “Role of N-terminal protein formylation for central metabolic processes in Staphylococcus aureus”
• Liebeke, M., Bundy, JG. (2013), Biochemical and Biophysical Research Communications 430(4), 1306-1311 “Biochemical diversity of betaines in earthworms”
• Geiger, T., Francois, P., Liebeke, M., Frauenholz, M., Goerke, C., Krismer, B., Schrenzel, J., Lalk, M., Wolz, C. (2012), PloS Pathogens 8(11): e1003016, “The Stringent Response of Staphylococcus aureus and its involvement in surviving phagocytosis through the induction of intracellular PSMs expression.”
• Liebeke, M., Bundy, JG. (2012), Metabolomics 8:819–830, “Tissue disruption and extraction methods for metabolic profiling of an invertebrate sentinel species”
• Kleiner, M., Wentrup, C., Lott, C., Teeling, H., Wetzel, S., Young, J., Chang, J., Shah, M., VerBerkmoes, N., Zarzycki, J., Fuchs, G., Markert, S., Hempel, K., Voigt, B., Becher, D., Liebeke, M., Lalk, M., Albrecht, D., Hecker, M., Schweder, T., Dubilier, N. (2012), PNAS 109 (19):E1173-82, “Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use"
• Reiss, S., Pane-Farre, J., Fuchs, S., Francois, P., Liebeke, M., Lalk, M., Schrenzel, J., Wolz, C., Hecker, M., Engelmann, S. (2012), Antimicrobial Agents and Chemotherapy 56 (2):787-804, “Global analysis of the Staphylococcus aureus response to mupirocin”
• Birkenstock, T.*; Liebeke, M.*; Winstel, V.; Krismer, B.; Gekeler, C.; Niemiec, MJ; Bisswanger, H.; Lalk, M.; Peschel, A. (2012), Journal of Biological Chemistry, 287 (4):2887–95, “Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens.”
• Liebeke, M., Dorries, K., Meyer, H., Lalk, M. (2012), Methods Mol Biol  815, 377-398 , “Metabolome Analysis of Gram-Positive Bacteria such as Staphylococcus aureus by GC-MS and LC-MS” – book chapter-
• Tredwell, G., Behrend, V., Geier, FA., Liebeke, M., Bundy, JG. (2011) Analytical Chemistry 15; 83(22): 8683-7, “Between-person comparison of metabolite fitting for NMR-based quantitative metabolomics”
• Liang, CG.; Liebeke, M.; Schwarz, R.; Zuhlke, D.; Fuchs, S.; Menschner, L.; Engelmann, S.; Wolz, C.; Jaglitz, S.; Bernhardt, J.; Hecker, M; Lalk, M.; Dandekar, T. (2011), Proteomics 11, 1915–35, “Staphylococcus aureus physiological growth limitations: Insights from flux calculations built on proteomics and external metabolite data.”
• Leibig, M., Liebeke, M., Mader, D., Lalk, M., Peschel, A., Gotz, F. (2010), J Bacteriology 193(4): 952–62,  Pyruvate formate lyase acts as a formate supplier for metabolic processes under anaerobiosis in Staphylococcus aureus”
• Liebeke, M.*, Dorries, K.*, Zuhlke, D.*, Bernhardt, J; Fuchs, S; Pane-Farre, J; Engelmann, S; Volker, U; Bode, R; Dandekar, T; Lindequist, U; Hecker, M; Lalk, M (2011), Molecular BioSystems 7, 1241–53, “A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation.”
• Wilmes, B., Hartung, A., Lalk, M., Liebeke, M., Schweder, T., Neubauer, P. (2010), Microbial Cell Factories 9: 72, “Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis“
• Liebeke, M., Meyer, H., Donat, S., Ohlsen, K., Lalk, M. (2010), Chemistry and Biology 17: 820–30, “A Metabolomic View of Staphylococcus aureus and Its Ser/Thr Kinase and Phosphatase Deletion Mutants: Involvement in Cell Wall Biosynthesis.”
• Thanh, T., Jurgen, B., Bauch, M., Liebeke, M., Lalk, M., Ehrenreich, A., Evers, S., Maurer, KH., Antelmann, H., Ernst, F., Homuth, G., Hecker, M., Schweder, T. (2010), Appl Microbiol Biotechnol, 87:2227–35, “Regulation of acetoin and 2,3-butanediol utilization in Bacillus licheniformis”
• Meyer, H.*, Liebeke, M.*, and Lalk, M. (2010), Analytical Biochemistry 401:250–9, A protocol for the investigation of the intracellular Staphylococcus aureus metabolome.”
• Liebeke, M., Wunder, A., Lalk, M. (2009), Analytical Biochemistry 401:312–4, “A rapid microwave-assisted derivatization of bacterial metabolome samples for gaschromatography/mass spectrometry analysis.”
• Pagels, M., Fuchs, S., Pané-Farré, J., Kohler, C., Menschner, L., Hecker, M., McNamarra, P.J., Bauer, M.C., Wachenfeldt, C.v., Liebeke, M., Lalk, M., Sander, G., Eiff, C.v., Proctor, R.A., and Engelmann, S. (2010)  Molecular Microbiology 76(5):1142–61, “A redox sensing mechanism by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus.”
• Geiger, T., Goerke, C., Fritz, M., Schäfer, T., Ohlsen, K., Liebeke, M., Lalk, M., Wolz, C. (2010), Infection and Immunity 78(5):1873–83, “Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.”
• Gaupp, R., Schlag, S., Liebeke, M., Lalk, M., and Gotz, F. (2010), J Bacteriology 192(9): 2385–94, “Advandage of up-regulation of succinate dehydrogenase in Staphylococcus aureus biofilm.”
• Pother, D.C.*, Liebeke, M.*, Hochgrafe, F., Antelmann, H., Becher, D., Lalk, M., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y., and Hecker, M. (2009), J Bacteriology 191(24): 7520–30, “Diamide triggers mainly S-thiolations in the cytoplasmic proteome of Bacillus subtilis and Staphylococcus aureus.”
• Michalik, S., Liebeke, M., Zuhlke, D., Lalk, M., Bernhardt, J., Gerth, U., and Hecker, M. (2009)  Proteomics 9 (19): 4468-77, “Proteolysis during long-term glucose starvation in Staphylococcus aureus COL.”
• Hamberger, J.; Liebeke, M.; Kaiser, M., Bracht, K.; Olszewski, U.; Zeillinger, R.; Hamilton, G.; Braun, D.; Bednarski, PJ. (2009), Anticancer-Drugs, 20: 559-72, “Characterisation of chemosensitivity and resistance of human cancer cell lines to platinum(II) and platinum(IV) anticancer agents.”
• Donat, S., Streker, K., Schirmeister, T., Rakette, S., Stehle, T., Liebeke, M. ; Lalk, M.; Ohlsen, K. (2009)  J Bacteriology 191(13): 4056-69, “Transcriptome and functional analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus.”
• Liebeke, M., Brozel, V.S., Hecker, M., and Lalk, M. (2009), Applied Microbiology Biotechnol 83: 161-73, “Chemical characterization of soil extract as growth media for the ecophysiological study of bacteria.”
• Nguyen, T.T., Eiamphungporn, W., Mader, U., Liebeke, M., Lalk, M., Hecker, M., Antelmann, H., Helmann, JD (2009), Molecular Microbiology 71: 876-94, “Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol- dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR- family regulator YraB (AdhR).”
• Schlag, S., Fuchs, S., Nerz, C., Gaupp, R., Engelmann, S., Liebeke, M., Lalk, M., Hecker, M., Goetz, F. (2008), J Bacteriology 190: 7847-58, “Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus.”
• Kohler, C., von Eiff, C., Liebeke, M., McNamara, P.J., Lalk, M., Proctor, R.A., Hecker, M., Engelmann, S. (2008), J Bacteriology 190: 6351-64, “A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus.”
• Liebeke, M.*, Pother, D.C.*, van Duy, N., Albrecht, D., Becher, D., Hochgrafe, F., Lalk, M., Hecker, M., Antelmann, H. (2008), Molecular Microbiology 69: 1513-29, “Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis.”
• Hochgrafe, F., Wolf, C., Fuchs, S., Liebeke, M., Lalk, M., Engelmann, S., and Hecker, M. (2008)  J Bacteriology 190: 4997-5008, “Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus.”
• Bracht, K., Liebeke, M., Ritter, C.A., Grunert, R., and Bednarski, P.J. (2007), Anticancer Drugs 18: 389-404, “Correlations between the activities of 19 standard anticancer agents, antioxidative enzyme activities and the expression of ATP-binding cassette transporters: comparison with the National Cancer Institute data.”
• Saczewski, J., Brzozowski, Z., Saczewski, F., Bednarski, P.J., Liebeke, M., and Gdaniec, M. (2006)  Bioorganic & Medicinal Chemistry Letters 16: 3663-67, “Synthesis and in vitro anti-tumor activity of N-{1- (3-thioxo-5,6-dihydroimidazo 2,1-c 1,2,4 thiadiazol-7ylthio)thio carbonyl -2-imidazolidene}arylsulfonamides.” 

Metabolomik ist eine Schlüsselmethode in den modernen Lebenswissenschaften, um den Einfluss des Mikrobioms auf unsere Biologie zu ergründen. Sie ermöglicht es, chemische Signale zu entschlüsseln, die das Mikrobiom an die Umgebung sendet. Dabei werden molekulare Stoffwechselverbindungen in biologischen Systemen analytisch erfasst. Gemeinsam mit seinem Team arbeitet Manuel Liebeke am Aufbau einer Metabolomik-Plattform, die in der gesamten Kieler Uni genutzt werden kann.

Die Forschung im Labor wird ständig von Methodenentwicklungen wie der hochauflösenden Massenspektrometrie und Fluoreszenzmikroskopie vorangetrieben, um das räumliche Metabolom von mikrobiellen Systemen aufzudecken.

Forschungsprojekte:

- tbc