RTF IV: Experimental Models of Inflammation

Coordinators: R. Ludwig (UzL), J. Baines (CAU, MPI), J. Köhl (UzL), A. Scheffold (CAU)

RTF IV is an interdisciplinary platform, which develops and provides individualized mouse models for chronic inflammatory barrier diseases, such as inflammatory bowel disease (IBD). In particular, individual changes of patients are investigated in the genome and the microbiome, e.g. through organoids, specialized cell models which were generated from the cells of diseased patients and then transferred into mice. We also offer high-resolution immunological, genetic and imaging techniques, in order to investigate the cellular and molecular mechanisms that underlie the development and regulation of inflammatory diseases.

What does this research area’s work build on

The Max Planck Institute for Evolutionary Biology in Plön, in cooperation with Kiel University, has a gnotobiotic lab in a new, state-of-the-art mouse facility. This enables the researchers to investigate sterile (germ-free) animals, and conduct fecal transplantation and colonization experiments, which are key projects of TI-1, for example. The Institute of Immunology in Kiel and the Institute for Systemic Inflammation Research in Lübeck also offer central cytometry platforms, which enable high-resolution cell sorting and multi-parameter characterization of disease-relevant cell populations for the different cluster projects.

 

What are the main research objectives?

The main goal of this research area is to provide individualized experimental models for patient groups, in order to define individual disease principles and treatment strategies, while taking into account the most important aspects of patient genome and microbiome, i.e. the hologenome. In particular, those involved will develop or further improve state-of-the-art, individualized mouse models of inflammatory diseases. In doing so, the identification and characterization of disease-relevant cell populations through state-of-the-art cytometry is an essential step within precision medicine.
 

 

What makes this research area special?

The research area has great potential to define new aspects of genetic, immunological and microbial factors which drive the development of diseases, including the transition from non-harmful microorganisms living in symbiosis to harmful microorganisms, and the associated immunological processes.

 

What does the research area contribute to precision medicine in chronic inflammation?

RTF IV provides state-of-the-art experimental in vivo models, as well as a platform for high-resolution immunological cell analysis of clinical samples and samples from the experimental models. These approaches enable the validation of new therapeutic target structures, the evaluation of personalized therapeutic approaches including the influence of the microbiome and the identification of new molecular mechanisms underlying chronic inflammatory diseases.

 

Cooperation with other research areas in the cluster

RTF IV works closely together with RTF I, RTF II and TI-1, from which it obtains the data of the individual genomic and metagenomic differences between the patients. The high-resolution immunological cell analysis is provided for TIs 2-4 and CDs 1-5, and thus fulfils a central function in the cluster.

 

Members

M. Sc. Ligia Abrante Cabrera

Associated member

UKSH Campus Kiel
Institute of Clinical Chemistry
AG PD Leypoldt

Prof. Dr. rer. nat. Dieter Adam

Full member

UKSH Campus Kiel
Department of Immunology

Priv.-Doz. Dr. Konrad Aden

Full member

UKSH Campus Kiel
Department of Internal Medicine I

Dr. Nadia Adreani

Associated member

Max Planck Institute for Evolutionary Biology
Institute of Experimental Medicine
RG Prof. Baines

Dr. Zouhair Aherrahrou

Associated member

University of Lübeck
Institute for Cardiogenetics

Prof. Dr. rer. nat. Petra Bacher

Full member

UKSH Campus Kiel
Department of Immunology

Prof. Dr. John Baines

Full member

Max Planck Institute for Evolutionary Biology
Institute of Experimental Medicine
Evolutionary Genomics

Prof. Dr. Christoph Becker-Pauly

Full member

Kiel University
Institute of Biochemistry
Degradomics of the Protease Web

Dr. Meriem Belheouane

Associated member

Max Planck Institute for Evolutionary Biology
Institute of Experimental Medicine
RG Evolutionary Genomics

PD Dr. Katja Bieber

Associated member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology

Dr. Florian Bleibaum

Associated member

Kiel University
Institute of Biochemistry
Molecular Cell Biology and Transgenic Research
AG Prof. Saftig

Prof. Dr. rer. nat. Dr. h. c. Thomas Bosch

Full member

Kiel University
Institute of Zoology
Cell and Developmental Biology

Martina Bucsaiova

Associated member

UKSH Campus Lübeck
Department of Infectious Diseases and Microbiology
AG Prof. Verschoor

Dr. rer. nat. François Cossais

Associated member

Kiel University
Department of Anatomy

Dr. Robert Creutznacher

Associated member

University of Lübeck
Institute for Chemistry and Metabolomics
AG Prof. Peters

Dr. Stefanie Derer

Full member

UKSH Campus Lübeck
Institute of Medical Nutrition Science
RG Molecular Gastroenterology

Prof. Dr. Marc Ehlers

Full member

UKSH Campus Lübeck
Institute of Medical Nutrition Science
Immunology and Glycoanalytics

Prof. Dr. Jeanette Erdmann

Full member

University of Lübeck
Institute for Cardiogenetics

Prof. Dr. Heinz Fehrenbach

Full member

Research Center Borstel - Leibniz Lung Center
Experimental Pneumology
Priority Research Area Asthma and Allergy

Prof. Dr. Sabine Fuchs

Full member

UKSH Campus Kiel
Department of Trauma Surgery
Experimental Orthopaedics and Trauma Surgery

Dr. Alibek Galeev

Associated member

Kiel University
Institute of Experimental Medicine
AG Prof. Unterweger

Prof. Dr. Timo Gemoll

Associated member

UKSH Campus Lübeck
Department of General Surgery

Prof. Dr. Torsten Goldmann

Full member

Research Center Borstel - Leibniz Lung Center
Pathology
Medicine

Dr. rer. nat. Simon Graspeuntner

Associated member

UKSH Campus Lübeck
Department of Infectious Diseases and Microbiology
AG Prof. Rupp

Dr. Yask Gupta

Associated member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Model Systems of Inflammatory Skin Diseases

Dr. Christoph M. Hammers

Associated member

UKSH Campus Lübeck
Department of Dermatology, Allergology and Venerology

Prof. Dr. rer. nat. Jürgen Harder

Full member

UKSH Campus Kiel
Department of Dermatology, Venereology and Allergology

Prof. Dr. rer. nat. Robert Häsler

Full member

Kiel University
Institute of Clinical Molecular Biology
Molecular Cell Biology

Priv.-Doz. Dr. rer. nat. Kirsten Hattermann-Koch

Associated member

Kiel University
Department of Anatomy
Molecular Cell and Neurobiology/Neurobiochemistry

Prof. Dr. med. Guido Heine

Full member

UKSH Campus Kiel
Department of Dermatology, Venereology and Allergology

Dr. Christoph Hölscher

Full member

Research Center Borstel - Leibniz Lung Center
Infection Immunology
Priority Research Area Infections

Prof. Dr. Jan-Bernd Hövener

Full member

MOIN CC
Department of Radiology and Neuroradiology
Biomedical Imaging

Prof. Dr. med. Bimba Franziska Hoyer

Full member

UKSH Campus Kiel
Department of Internal Medicine I
Section Rheumatology

Prof. Dr. Jennifer Hundt

Full member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology

Prof. Dr. rer. nat. Andreas Hutloff

Full member

UKSH Campus Kiel
Department of Immunology

Prof. Dr. Saleh Ibrahim

Full member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Genetics of Inflammatory Diseases

Prof. Dr. Sabrina Jabs

Full member

Kiel University
Institute of Clinical Molecular Biology
RG Prof. Rosenstiel

Prof. Dr. med. Dietrich Kabelitz

Full member

UKSH Campus Kiel
Department of Immunology

PD Dr. Kathrin Kalies

Full member

University of Lübeck
Institute for Anatomy

Prof. Dr. Christian Karsten

Full member

University of Lübeck
Institute for Systemic Inflammation Research

Dr. Anika Kasprick

Associated member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Model Systems of Inflammatory Skin Diseases

Prof. Dr. Claudia Kemper

Full member

University of Lübeck
Institute for Systemic Inflammation Research

Mirjam Knop

Associated member

Kiel University
Institute of Zoology
AG Prof. Roeder

Prof. Dr. Peter König

Full member

University of Lübeck
Institute for Anatomy

Prof. Dr. rer. nat. Stefan Krautwald

Vollmitglied

UKSH Campus Kiel
Department of Internal Medicine IV
Department for Nephrology and Hypertension

Prof. Dr. med. Ulrich Kunzendorf

Full member

UKSH Campus Kiel
Department of Internal Medicine IV

PD Dr. Yves Laumonnier

Associated member

University of Lübeck
Institute for Systemic Inflammation Research

Priv.-Doz. Dr. med. Frank Leypoldt

Full member

UKSH Campus Kiel
Institute of Clinical Chemistry
Central laboratory

Prof. Dr. Ralph Lucius

Full member

Kiel University
Department of Anatomy

Prof. Dr. Ralf Ludwig

Full member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Model Systems of Inflammatory Skin Diseases

Prof. Dr. Rudolf Manz

Full member

University of Lübeck
Institute for Systemic Inflammation Research

Prof. Dr. rer. physiol. Edmund Maser

Full member

UKSH Campus Kiel
Institute of Toxicology and Pharmacology for Natural Scientists

Dr. Jeroen R. Mesters

Full member

University of Lübeck
Institute for Biochemistry

Prof. Dr. Thomas F. Meyer

Full member

UKSH Campus Kiel
Institute of Clinical Molecular Biology
Senior RG Infection Oncology

Prof. Dr. med. Oliver Müller

Full member

UKSH Campus Kiel
Department of Internal Medicine III
Translational Cardiology

Prof. Dr. Henrik Oster

Full member

University of Lübeck
Institute of Neurobiology
Chronobiology

PD Dr. Andreas Recke

Full member

UKSH Campus Lübeck
Department of Dermatology, Allergology and Venerology

Prof. Dr. Gabriela Riemekasten

Full member

UKSH Campus Lübeck
Department of Rheumatology and Clinical Immunology

Prof. Dr. rer. nat. Thomas Roeder

Full member

Kiel University
Institute of Zoology
Molecular Physiology

Prof. Dr. Stefan Rose-John

Full member

Kiel University
Institute of Biochemistry
Cytokine and Metalloproteinase Research

Prof. Dr. med. Philip Rosenstiel

Full member

Kiel University
Institute of Clinical Molecular Biology
Molecular Cell Biology

Prof. Dr. Christian Sadik

Full member

UKSH Campus Lübeck
Department of Dermatology, Allergology and Venerology
Innate immunity

Prof. Dr. rer. nat. Heiner Schäfer

Full member

UKSH Campus Kiel
Institute of Experimental Cancer Research
c/o Department of Internal Medicine I

Prof. Dr. Ulrich Schaible

Full member

Research Center Borstel - Leibniz Lung Center
Cellular Microbiology
Priority Research Area Infections

Prof. Dr. rer. nat. Alexander Scheffold

Full member

UKSH Campus Kiel
Department of Immunology

Prof. Dr. Dr. Enno Schmidt

Full member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Translational Research

Prof. Dr. Andra Schromm

Full member

Research Center Borstel - Leibniz Lung Center
Immunobiophysics
Priority Research Area Infections

Prof. Dr. Hinrich Schulenburg

Full member

Kiel University
Institute of Zoology
Evolutionary Ecology and Genetics

Prof. Dr. Markus Schwaninger

Full member

University of Lübeck
Institute for Experimental and Clinical Pharmacology and Toxicology

Dr. oec. troph. Ina Suhrkamp

Associated member

UKSH Campus Kiel
Department of Dermatology, Venereology, and Allergology
AG Prof. Heine

Prof. Dr. Diethard Tautz

Full member

Max Planck Institute for Evolutionary Biology
Evolutionary Genetics

Prof. Dr. Bernhard Thalheim

Full member

Kiel University
Department of Computer Science
Information System Engineering

Prof. Dr. Andreas Tholey

Full member

UKSH Campus Kiel
Institute of Experimental Medicine
Systematic Proteomics

Prof. Dr. Daniel Unterweger

Full member

Max Planck Institute for Evolutionary Biology
Evolutionary Genomics

Prof. Dr. Admar Verschoor

Full member

UKSH Campus Lübeck
Department of Infectious Diseases and Microbiology

Dr. Artem Vorobyev

Associated member

UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Model Systems of Inflammatory Skin Diseases

Prof. Dr. Daniela Wesch

Full member

UKSH Campus Kiel
Department of Immunology

Prof. Dr. Jürgen Westermann

Full member

University of Lübeck
Institute for Anatomy

Prof. Dr. Xinhua Yu

Full member

Research Center Borstel - Leibniz Lung Center
Pulmonary Immune Diseases
Priority Research Area Asthma and Allergy

Prof. Dr. Detlef Zillikens

Full member

UKSH Campus Lübeck
Department of Dermatology, Allergology and Venerology