„Miniproposals“: Cluster of Excellence PMI funds 22 projects of its young researchers

The research projects of the cluster's young scientists were selected by an external team of reviewers.

In spring 2021, the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI) invited its young scientists to submit applications for funding of research projects (so-called "miniproposals") dealing with highly innovative questions in inflammation research. From 56 applications, with the help of external reviewers 22 projects were selected to be funded by the cluster. The selection criteria were innovation and novelty of the scientific question, methodology, relevance in relation to the topics of inflammation research, excellence in scientific thinking, and stringency in the project description.

 

Logo PMI - Precision Medicine in Chronic Inflammation

The following young cluster members and projects are funded in 2021:

Name and Institute

Project titel

Dr. Nina van Beek
Klinik für Dermatologie, Allergologie & Venerologie
UKSH Lübeck

Genotyping in bullous pemphigoid - a validation study and prerequisite for gene-gene interaction and mendelian randomization studies

Dr. Florian Bleibaum
Biochemisches Institut
Molecular Cell Biology & Transgenic Research
CAU Kiel

Applied co-expression network analysis for the identification of new lysosomal proteins and functional analysis of NHLRC3 role in inflammation and endothelial cell homeostasis

Kathrin Boersch
Institut für Klinische Molekularbiologie
CAU Kiel

"Statusplus® Probandenportal" - sharing study results with subjects. Expansion of the website for broad use in the Cluster of Excellence PMI in the field of inflammation research, at the example of the MS Cohort and ITM blood donor cohort of the UKSH

Dr. Daniela Esser
Institut für Klinische Chemie
Neuroimmunologie
UKSH Kiel

Precision medicine in neuroimmunology: Prognostic markers for response to B-cell depletion in autoimmune syndromes of the central nervous system

Dr. Alibek Galeev
Institut für Experimentelle Medizin
CAU Kiel / MPI Plön

Establishing a lung organoid model for inflammation research

Madita Göb
Institut für Biomedizinische Optik
Universität zu Lübeck

Robotically assisted ultra-large area Optical Coherence Tomography for pre-symptomatic detection and monitoring of inflammatory skin diseases

Jonathan F. Josephs-Spaulding
Institut für Experimentelle Medizin
Medical Systems Biology
CAU Kiel

Unraveling PFAS Toxicity Mechanisms of Chronic Inflammation Through Gene (Dys)regulatory Networks and Microbiome Pathways: Towards a Systems Toxicology Pilot Study

Prof. Dr. Sebastian Karpf
Institut für Biomedizinische Optik
Universität zu Lübeck

4D SLIDE - Video-rate 3D Two-Photon Imaging for visualizing inflammation in vivo

Prof. Dr. Ben Krause-Kyora
Institut für Klinische Molekularbiologie
Ancient DNA Research
CAU Kiel

On the origin and evolution of IBD-associated variants

Prof. Dr. Matthias Merker
Molekulare und Experimentelle Mykobakteriologie
Forschungszentrum Borstel

Analysis of the gut and lung microbiome in bacterial infections and inflammatory diseases of the lower respiratory tract

Dr. Neha Mishra
Institut für Klinische Molekularbiologie
CAU Kiel

Immunomodulation of blood cells through epigenetic and transcriptional reprogramming by TNF antagonists

Lena Möbus
Klinik für Dermatologie, Venerologie & Allergologie
UKSH Kiel

Single-cell RNA sequencing of cutaneous immune cells in atopic dermatitis and psoriasis: a pilot study to establish workflows and generate preliminary data

Dr. Andrey Pravdivtsev
Klinik für Radiologie & Neuroradiologie
Sektion Biomedizinische Bildgebung
CAU Kiel

13C-MR-imaging for spontaneous adenocarcinoma and inflammatory bowel disease mouse models

Dr. Wiebke Prüßmann
Klinik für Dermatologie, Allergologie & Venerologie
UKSH Lübeck

The role of PD-L1/PD-1 immune checkpoint molecules in pemphigoid diseases

Dr. Sascha Rahn
Biochemisches Institut
CAU Kiel

Characterization of a genetic mouse model for systemic inflammation: A novel tool to unravel molecular hallmarks and therapeutic targets in sepsis?

Dr. Tobias Reinberger
Institut für Kardiogenetik
Universität zu Lübeck

Transcriptome analysis and identification of RNA modifications in vascular smooth muscle cells under oxidative stress using oxford nanopore (ONT) direct RNA sequencing

Dr. Elisa Rosati
Institut für Klinische Molekularbiologie
CAU Kiel

A new molecular sub-phenotype of Crohn’s disease: Characterization and application in precision medicine

Dr. Anja Schumann
Klinik für Rheumatologie & klinische Immunologie
UKSH Lübeck

Resolving physiological and pathophysiological roles of functional autoantibodies targeting G protein-coupled receptors using lipid nanoparticle technology

Dr. Kolja Them
Klinik für Radiologie & Neuroradiologie
Sektion Biomedizinische Bildgebung
CAU Kiel

A new method for MR signal amplification of key molecules of metabolic inflammation

Dr. Florian Tran
Institut für Klinische Molekularbiologie
CAU Kiel / Innere Medizin I, UKSH Kiel

Spatial Multi-Omics Phenotyping of Intestinal Tissue in Ulcerative Colitis

Dr. Leif Tüffers
Zoologisches Institut
Evolutionsökologie & -genetik
CAU Kiel

Bacterial responses to evolution-informed antibiotic therapy-resistance and microbiome monitoring in an interventional study

Prof. Dr. Silvio Waschina
Institut für Humanernährung und Lebensmittelkunde
Nutriinformatik
CAU Kiel

Sharing essential nutrients – Elucidating the role of tryptophan auxotrophies within the gut microbiota in chronic inflammation