Can long-lasting molecular changes in diseased cells be reversed?

Coordinators: H. Kirchner (UzL), S. Jabs (CAU), F.-J. Müller (CAU) P. Rosenstiel (CAU)

Chronic inflammation can leave a lasting molecular imprint on cells. One way this happens is through epigenetic changes: modifications that alter how genetic information is used without changing the DNA sequence itself. Such changes may perpetuate chronic inflammation even when the original trigger is no longer present.

RTF-III investigates how these altered cellular programs arise and persist in chronic inflammatory diseases. We study changes to DNA, RNA and proteins associated with DNA, using patient-derived cells and preclinical models.

The ultimate goal is not only to understand these molecular switches, but to manipulate them. New technologies, including CRISPR-based approaches, will be used to explore whether diseased cells can be reprogrammed towards a healthier state – potentially opening new avenues for therapies that target the mechanisms maintaining chronic inflammation.