RTF I: Genomic diversity in chronic inflammatory diseases
Coordinator:AndreFranke(CAU)
RTFIemployslargecohortsandgeneticdatainordertoimproveourunderstandingofthecausesofchronicinflammatorydiseases.Forthispurpose,extensivesequencingdataiscombinedwithotherhigh-dimensionaldataandcontinuouslyupdatedclinicalinformation.AsakeyresourceinPMI,RTFIaimstogenerateGermany'slargestgeneticdatasetforinflammatorydiseases.
What does this research area’s work build on?
Inrecentyears,extensivegeneticmapshavebeencreatedforvariousinflammatorydiseases,i.e.wenowknowmostcommongeneticriskfactors.ThereforethescientistsinRTFIhaveexperiencewithidentifyinggeneticriskfactorsandhavebuiltuptheappropriateresourcesfordoingso,suchasmappingtechnologiesandanalyticsaswellaslargeDNAcollections.
What are the main research objectives?
ThemaingoalsofRTFIare
- generatingoneofthebiggestinflammationcohortdatasetsforgenetic,clinicalandepidemiologicalresearch,
- identifyingandcharacterizingnewdiseasegenes,andinparticulardetectinganddeterminingthefrequently"hidden"monogeniccases,
- identifyingrarevariantsandstudygeneticresistance,so-calledresilience,
- identifyingclinicalphenotypesthatareassociatedwithgeneticvariantsoftheknownfunction(PheWAS),
- verifyingnewpharmacogenomicvariantsfortargetedinflammationtherapiesand
- identifyingriskandprotectivefactorsinfirst-degreerelativesofpatientswithchronicinflammatorydiseases.
What makes this research area special?
AuniquefeatureispatienteducationandourinformedpatientconsentthatisusedattheUSKHinKiel,theso-called"broadconsent".Onthisbasis,theresearcherswereabletobuildupanintegratedbiobankinhospitaloperations,whichwetermhealthcare-integratedbiobanking.Patientsandphysicianssupporttheresearchwithdataandsampleswithoutanyrestrictionstoroutinehealthcare.Withthehelpofthisinfrastructure,thescientistshavecollectedsamplesanddatafromover20,000patients(statusJanuary2020,furtherinformation:https://www.uksh.de/kohorte/en/)attheUSKHforPMIresearchpurposessofar.RTFIisplanningageneticanalysisoftheentirecohortandwantstogenerateGermany'slargestgeneticdatasetforinflammatorydiseases.
What does the research area contribute to precision medicine in chronic inflammation?
RTFIwillmakeanimportantcontributiontoprecisionmedicinebyidentifyingandresolving"hidden"monogenicandoligogeniccausesofdiseaseinpatientsfromthenormalhospitalroutine.Thereclassificationofthediseasemanifestation,theidentificationofefficientpreclinical/subclinicaldisordersandpharmacogenomicmarkersareprerequisitesforeachprecisionmedicineapproachandimportantpointsintheRTFIresearchprogram.Cross-diseaseanalyseswillhelptoidentifybothcommonaswellasdisease-specificsusceptibilityfactors,revealpleiotropicvariants,highlightcomprehensivetreatmentpathsandenableabetterunderstandingofthecomorbidities.Overall,RTFIstrivesforacompletedissolutionofthegenetictaxonomyofinflammatorydiseasesandtheirpossibletransferintoclinicalcareatanindividuallevel.
Cooperation with other research areas in the cluster
- RTFIIforintegrationofthemicrobiomedata
- RTFVIforsequence-basedanalyses
- RTFXforfamilystudies("kindredcohorts")andclinicalcohortsfromtheCCIMs.
Members
Dr. Zouhair Aherrahrou
Associated member
University of Lübeck
Institute for Cardiogenetics
Prof. Dr. rer. nat. Norbert Arnold
Full member
UKSH Campus Kiel
Department of Gynecology and Obstetrics
Laboratory of Oncology
Prof. Dr. rer. nat. Petra Bacher
Full member
UKSH Campus Kiel
Department of Immunology
Prof. Dr. John Baines
Full member
Max Planck Institute for Evolutionary Biology
Institute of Experimental Medicine
Evolutionary Genomics
Prof. Dr. Lars Bertram
Full member
University of Lübeck
Lübeck Interdisciplinary Platform for Genome Analytics (LIGA)
Prof. Dr. Hauke Busch
Full member
UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
System Biology of Inflammatory Diseases
Prof. Dr. med. Dr. rer. nat. Ingolf Cascorbi
Full member
UKSH Campus Kiel
Institute of Clinical and Experimental Pharmacology
Prof. Dr. rer. nat. Astrid Dempfle
Full member
UKSH Campus Kiel
Institute of Medical Informatics and Statistics
Prof. Dr. Ingo Eitel
Full member
UKSH Campus Lübeck
Medical Department II
Prof. Dr. David Ellinghaus
Full member
Kiel University
Institute of Clinical Molecular Biology
Centre for Molecular Biosciences
Dr. Eva Ellinghaus
Full member
Kiel University
Institute of Clinical Molecular Biology
Centre for Molecular Biosciences
Prof. Dr. rer. nat. Andre Franke
Full member
Kiel University
Institute of Clinical Molecular Biology
Genetics & Bioinformatics
Dr. Jeanette Franzenburg
Associated member
Kiel University
Institute of Clinical Molecular Biology
AG Prof. Franke
Dr. rer. nat. Sandra Freitag-Wolf
Associated member
UKSH Campus Kiel
Institute of Medical Informatics and Statistics
Prof. Dr. Timo Gemoll
Associated member
UKSH Campus Lübeck
Department of General Surgery
M. Sc. Maria Gretsova
Associated member
Kiel University
Institute of Clinical Molecular Biology
AG Prof. Ellinghaus
Dr. rer. hum. biol. Yask Gupta
Associated member
UKSH Campus Lübeck
Institute for Inflammation Medicine
AG Prof. Thaçi
Dr. Seirana Hashemi
Associated member
Kiel University
Institute of Clinical Molecular Biology
Centre for Molecular Biosciences
AG Prof. Ellinghaus
Dr. rer. nat. Matthias Hübenthal
Associated member
UKSH Campus Kiel
Department of Dermatology, Venereology and Allergology
AG Prof. Weidinger
Prof. Dr. Saleh Ibrahim
Full member
UKSH Campus Lübeck
Lübeck Institute for Experimental Dermatology
Genetics of Inflammatory Diseases
Prof. Dr. Josef Ingenerf
Full member
University of Lübeck
Institute for Medical Informatics
Prof. Dr. med. Ralf Junker
Full member
UKSH Campus Kiel
Institute of Clinical Chemistry
Central laboratory
Prof. Dr. Christine Klein
Full member
University of Lübeck
Institute of Neurogenetics
Prof. Dr. Inke König
Full member
University of Lübeck
Institute for Medical Biometrics and Statistics
Prof. Dr. rer. nat. Ben Krause-Kyora
Full member
Kiel University
Institute of Clinical Molecular Biology
Ancient DNA Research
Prof. Dr. rer. nat. Michael Krawczak
Full member
UKSH Campus Kiel
Institute of Medical Informatics and Statistics
Prof. Dr. med. Wolfgang Lieb
Full member
Kiel University
Institute of Epidemiology
Dr. rer. nat. Britt-Sabina Löscher
Associated member
Kiel University
Institute of Clinical Molecular Biology
Centre for Molecular Biosciences
AG Prof. Franke
Dr. Inga Matthies
Associated member
UKSH Campus Kiel
Institute of Clinical Chemistry
AG Prof. Junker
Prof. Dr. rer. nat. Silke Meiners
Full member
Kiel University
Institute of Experimental Medicine
c/o Research Center Borstel - Leibniz Lung Center
Immunology and Cell Biology
Priority Research Area Chronic Lung Diseases
Prof. Almut Nebel
Full member
Kiel University
Institute of Clinical Molecular Biology
Longevity Ancient DNA Research
Prof. Dr. Dirk Nowotka
Full member
Kiel University
Department of Computer Science
Dependable Systems
Dr. Tobias Reinberger
Associated member
University of Lübeck
Institute for Cardiogenetics
AG Prof. Erdmann
Dr. agr. Kristina Schlicht
Associated member
UKSH Campus Kiel
Institute of Diabetes and Clinical Metabolic Research
AG Prof. Laudes
Prof. Dr. rer. nat. Ruth Schmitz-Streit
Full member
Kiel University
Institute of General Microbiology
Molecular Biology of Microorganisms
Prof. Dr. med. Stefan Schreiber
Spokesperson
Kiel University
Institute of Clinical Molecular Biology
Prof. Dr. Silke Szymczak
Full member
University of Lübeck
Institute for Medical Biometrics and Statistics
Prof. Dr. Diamant Thaçi
Full member
UKSH Campus Lübeck
Comprehensive Center for Inflammation Medicine (CCIM)
Prof. Dr. Stephan Weidinger
Full member
UKSH Campus Kiel
Department of Dermatology, Venereology and Allergology
Prof. Dr. Inken Wohlers
Associated member
Research Center Borstel - Leibniz Lung Center
Biomolecular Data Science in Pneumology
Prof. Dr. Elmar Wolf
Full member
Kiel University
Institute of Biochemistry
